DNA Vaccination/Genetic Vaccination
نویسندگان
چکیده
منابع مشابه
CEA Plasmid as Therapeutic DNA Vaccination against Colorectal Cancer
Background: Human colorectal cancer cells overexpress carcinoembryonic antigen (CEA). CEA is a glycoprotein which has shown to be a promising vaccine target for immunotherapy against colorectal cancer. Objective: To design a DNA vaccine harboring CEA antigen and evaluate its effect on inducing immunity against colorectal cancer cells in tumor bearing mice. <str...
متن کاملDNA vaccination against oncoantigens
The emerging evidence that DNA vaccines elicit a protective immune response in rodents, dogs and cancer patients, coupled with the US Food and Drug Administration (FDA) approval of an initial DNA vaccine to treat canine tumors is beginning to close the gap between the optimistic experimental data and their difficult application in a clinical setting. Here we review a series of conceptual and bi...
متن کاملDNA vaccination: an immunological perspective
La vacunación con DNA es una nueva y prometedora estrategia para la prevención y el tratamiento de muchas enfermedades debido a su habilidad para inducir una respuesta inmunitaria tanto humoral como celular, frente al antígeno codificado por el DNA recombinante. Una vez inoculado en el huésped, el DNA se introduce en las células, donde el antígeno se expresa y se procesa para ser después recono...
متن کاملM cell-targeted DNA vaccination.
DNA immunization, although attractive, is poor for inducing mucosal immunity, thus limiting its protective value against most infectious agents. To surmount this shortcoming, we devised a method for mucosal transgene vaccination by using an M cell ligand to direct the DNA vaccine to mucosal inductive tissues and the respiratory epithelium. This ligand, reovirus protein final sigma1, when conjug...
متن کاملIntralymphatic immunization enhances DNA vaccination.
Although DNA vaccines have been shown to elicit potent immune responses in animal models, initial clinical trials in humans have been disappointing, highlighting a need to optimize their immunogenicity. Naked DNA vaccines are usually administered either i.m. or intradermally. The current study shows that immunization with naked DNA by direct injection into a peripheral lymph node enhances immun...
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ژورنال
عنوان ژورنال: Journal of Medical Microbiology
سال: 1999
ISSN: 0022-2615,1473-5644
DOI: 10.1099/00222615-48-6-604